Dr. Friedlander has authored over 200 peer-reviewed publications in leading journals, including The New England Journal of Medicine, JAMA, JAMA Surgery, Nature, Nature Medicine, Nature Neuroscience, and Science. He is uniquely distinguished by having authored three single-author review articles in The New England Journal of Medicine, a rare accomplishment in modern academic medicine.

His clinical research has contributed to advances in the understanding and surgical management of Chiari malformation, including studies evaluating surgical techniques and demonstrating that cognitive and affective symptoms may improve following appropriately selected surgical treatment.

His scientific work includes seminal contributions to neuroscience, particularly in the study of neurodegenerative diseases such as Huntington’s disease and amyotrophic lateral sclerosis (ALS), advancing understanding of disease mechanisms and potential therapeutic approaches.